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Eurycoma longifolia for Testosterone Booster<\/p>\n
Eurycoma longifolia Jack\u00a0is a plant also known as\u00a0Longjack,\u00a0Malaysian Ginsengor\u00a0Tongkat Ali\u00a0that has gained notoriety as a symbol of man\u2019s ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities. The plant parts have been traditionally used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial and antipyretic (fever reduction) activities, which have also been proved scientifically. Moreover, the compounds of the roots of this plant are reported to have\u00a0aphrodisiac and testosterone enhancing effects\u00a0in the rats. Therefore, Eurycoma longifolia can be found in many testosterone boosters.<\/p>\n
There are plenty of animal studies using the rat as model showing that\u00a0Eurycoma longifolia\u00a0Jack (Longjack) supplementation\u00a0increased sexual motivation and performance including\u00a0increased serum testosterone\u00a0concentrations. It seems that\u00a0Eurycoma longifolia\u00a0produces a dose-dependent, recurrent and significant increase in the episodes of penile reflexes and\u00a0increase in mounting frequency. There\u00a0are, however, some studies that have failed to measure significant improvements in testosterone levels in normal rats after Eurycoma longifolia Jack supplementation.
\nOne very recent study in rats by Solomon and associates further investigated aphrodisiac effects of\u00a0Eurycoma longifolia\u00a0Jack (Longjack). Because previous studies were limited to only few sperm parameters or testosterone concentration,\u00a0Solomon and colleagues investigated the\u00a0in vivoeffects of\u00a0Eurycoma longifolia\u00a0Jack (Longjack) on body and organ weight as well as functional sperm parameters in terms of safety and efficacy in the management of male infertility. After 14 days of force-feeding researchers weighted sexual organs and muscles and assessed testosterone concentration, sperm concentration and mitochondrial membrane potential. There was no changes in organ weights,\u00a0testosterone concentration increased by 30.2%\u00a0(p\u00a0=\u00a00.0544),\u00a0muscle weight increased but not significantly, sperm concentration, motility and vitality increased significantly,\u00a0mitochondrial membrane potential improved by 25.1%(P\u00a0=\u00a00.0765).\u00a0 Bin-Seng Low and colleagues also reported\u00a0increase in plasma testosterone levels\u00a0when male rats were fed with 25\u00a0mg\/kg of\u00a0Eurycoma longifoliaJack extract. Compared to placebo significant difference in testosterone levels were evident at day 26 (p<0.05) and day 52 (P<0.01) but not at day 104. In contrast, the plasma estrogen level was significantly lower than that of the untreated control.<\/p>\n
The only human studies that are accessible online are in subjects with hypogonadism (diminished functional activity in the testes). 76 males were given 200\u00a0mg of a standardised water-soluble extract of\u00a0Eurycoma longifolia\u00a0Jack (Longjack) for 1\u00a0month. Results show that treatment of hypogonadic\u00a0patients with\u00a0Eurycoma longifolia\u00a0Jack extract significantly\u00a0(P\u00a0<\u00a00.0001)\u00a0improved the aging male syndrome score as well as the serum testosterone concentration. Interestingly one very recent study [23]\u00a0in healthy males\u00a0who received\u00a0200mg of\u00a0Eurycoma longifolia\u00a0and 100 mg of\u00a0Polygonum minus\u00a0demonstrated an\u00a0increase in total testosterone\u00a0(10.36%) but\u00a0decrease in free testosterone\u00a0(active testosterone). Which suggests that these two compounds (alone or in combination) may also increase sex-hormone binding globulin or increased metabolism and breakdown of free testosterone. When patients (75 completed one full cycle) suffering from infertility were given 200 mg of the\u00a0Eurycoma longifolia\u00a0Jack (Longjack) extract daily for 9 months sperm quality was significantly improved, allowing for 11 (14.7%) spontaneous pregnancies.
\nEurycoma longifolia\u00a0Jack (Longjack)\u00a0seems to increases testosterone levels in rats with hypogonadism\u00a0(or clinical\u00a0signs of hypogonadism). There is lack of studies on otherwise healthy rats. The only evidence on humans is also in persons with hypogonadism, other studies that claim increases of testosterone in healthy humans cannot be accessed online, are short and are of questionable quality.
\nAccording to WebMD.com : \u201cSome of the chemicals\u00a0seem to affect how the body produces the hormone testosterone. Research in animals and humans suggests\u00a0Eurycoma longifolia\u00a0might increase testosterone in the body.\u201d However, there is a possibility that\u00a0Eurycoma longifolia\u00a0may only work when there is testosterone deficiency\u00a0as\u00a0Eurycoma longifolia\u00a0supplementation to normal male rats failed to elevate the testosterone levels compared to nontreatment rats.<\/p>\n
When female rats were injected with testosterone, which lead to irregular estrous cycle thereby affecting the ovarian function, 50mg\/kg of a standardized quassinoid-rich extract (TAF 273) of Eurycoma root was able to improve irregular estrous cycles with less follicular morphological damage. It appears that potent anti-estrogenic effect\u00a0of Eurycoma (especially quassinoid Eurycomanone) was able to ameliorate the adverse effects of testosterone injection.<\/p>\n
It seems that daily supplementation with tongkat ali root extract improves stress hormone profile (reduced cortisol levels by 16% and increased testosterone status by 37%) [24]. Treatment group also exhibited significant improvements for tension (\u221211%), anger (\u221212%), and confusion (\u221215%) compared to placebo.<\/p>\n
Eurycoma longifolia\u00a0Jack\u00a0is normally recommended to be administered by men at the dose of 200\u2013400\u2009mg daily. The calculated acceptable daily intake is up to 1.2 g\/60 kg adult\/day. However, toxicological reports are incomplete and insufficient for demonstrating either long-term safety or prediction of acceptable daily intake.<\/p>\n
Even though toxicity and safety evaluation studies have been pursued, there is still\u00a0not enough information to know for sure if\u00a0Eurycoma longifolia\u00a0is safe. However, recent study in animals reported that\u00a0Eurycoma longifolia\u00a0appears safe for possible treatment of male infertility and ageing male problems. Results of one recent\u00a0in vitro\u00a0study\u00a0 indicate that the\u00a0Eurycoma longifolia\u00a0extract has no deleterious effects on sperm functions at therapeutically used concentrations. However, at very high doses, in may have harmful effects\u00a0in vitro. 600\u2009mg\/kg of\u00a0Eurycoma longifolia\u00a0Jack did not cause any adverse effects in a human clinical study. A recent study \u00a0reported that\u00a0Eurycoma longifolia\u00a0might be a\u00a0safe alternative to testosterone replacement therapy. Another very recent study \u00a0in healthy\u00a0males reported no liver and kidney abnormalities after supplementation with\u00a0300mg\u00a0combination of\u00a0Eurycoma longifolia\u00a0and\u00a0Polygonum minus\u00a0for 12 weeks. In rats, LD50<\/sub>\u00a0for Eurycoma has been found to be greater than 5000mg\/kg.
\nSource :<\/strong>\u00a0 Eurycoma longifolia for Testosterone Booster<\/a><\/p>\n